![]() ![]() familiarity with current approaches to educational assessment and evaluation and basic skills in measurement and research design and both quantitative and qualitative research methods.knowledge of atypical development and understanding of individuals with exceptionalities, and.an understanding of individual differences in development, learning and motivation,.knowledge of developmental theories and processes in the cognitive, social-emotional and cultural domains,.a basic knowledge of theories, principles and models of learning, development, and culture,.In principle, the following areas are considered to be essential to such a background: Learning ObjectivesĪll HDLC Doctoral students are expected to acquire a broad background in the study of Educational Psychology. ![]() HDLC graduates have found careers in a wide variety of settings including university teaching and research, social policy analysis, curriculum and program evaluation, community and business. These material extracts have inhibited cholesterol synthesis through a stronger HMGR inhibition than simvastatin.Īntihyperlipidemic apple peels high-density lipoprotein cholesterol hydroxy-3-methylglutaryl coenzyme A reductase low-density lipoprotein cholesterol triglyceride.Ĭopyright: © 2020 Journal of Advanced Pharmaceutical Technology & Research.The doctoral program in HDLC weaves together theoretical models and concepts in their application to real world educational issues. Quercetin could bind to HMGR at a similar location to amino acid residues as simvastatin. Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition. APE treatment with a dose of 114 mg/kg BW could significantly reduce LDLc and increase serum HDLc levels. This process places HMGR as a receptor and active compound of apple peels as a ligand. In silico inhibition test of HMGR activity was conducted by molecular docking using PyRx software. The total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDLc), and high-density lipoprotein cholesterol (HDLc) serum were measured. Hyperlipidemia rats were divided into four groups, with different doses of 0, 57, and 114 mg/kg BW of apple peel extract (APE) and simvastatin (3.6 mg/kg BW). In the present study, antihyperlipidemic material is tested for its effect in lowering lipid in animals and its proven ability to bind to HMGR. Simvastatin serves as a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitor, with prolonged use proven to cause side effects. Hyperlipidemia is generally managed with statin-based drugs. ![]()
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